Endocrine Abstracts

Introduction: Thyroid dysfunction affects quality of life (QoL) in untreated patients. However, patients with high thyroid autoantibodies complain about symptoms that resemble thyroid dysfunction even if they are euthyroid. The aim of this study was to evaluate QoL in euthyroid patients with elevated thyroid autoantibodies.Methods: Patients who admitted to Endocrinology clinic with symptoms of thyroid dysfunction and no other disease were included in the...

Description: Quality of life (QoL) is impaired in patients with thyroid dysfunction but has never been evaluated in patients with euthyroid nodular goiter (ENG). The aim of this study was to evaluate QoL in patients with ENG and compare the results with a healthy control group.Methods: Thirty patients with ENG (mean age 38.0 years, male/female=3/27) and 30 healthy, age and gender-matched euthyroid subjects without thyroid nodule (mean age 38.9 years, mal...

Introduction: The aim of this study was to compare quality of life among premenopausal women with vitamin D deficiency, vitamin D insufficiency and vitamin D sufficiency.Methods: Premenopausal women with chronic fatigue, myalgia and nonspecific body pain were divided according to their vitamin D levels: ≤20 ng/ml (vitamin D deficient, n=30), 21–29 ng/ml (vitamin D insufficient, n=30) and ≥30 ng/ml (vitamin D sufficient, ...

Inroduction: Progressive baldness and severe hirsutism associated with granulosa cell tumor of ovaries are rare conditions in women. Reported cases are usually pubertal girls and young women. Here, we report a case of postmenopausal baldness and hirsutism due to granulosa cell tumor of the ovary.Case report: A 62 year-old woman presented with baldness and hirsutism on her face, body and back for 3 years. She had menarche at 14 years and menopause at 52 y...

Introduction: Acromegaly is chronic debilitating disease related with excess GH and insülin-like growth factor 1 (IGF1) secretion. Pegvisomant is a GH receptor antagonist that competes with endogenous GH for its receptor and is often used as a medical therapy in patients with inadequate response to somatostatin analogs.Methods: Forty-six patients are followed with the diagnosis of acromegaly in our clinic. We present the results of six acromegalic p...

Objectıve: Due to increased usage of imaging modalities today, incidence of adrenal incidentaloma (AI) has increased. Insulin resistance is considered as the etiopathogenic mechanism. Since both insulin and IGF-1 are capable of interacting with same receptors, we aimed to investigate whether IGF-1 has a role in development of adrenal incidentaloma.Materıals and method: 50 female patients with nonfunctional adrenal incidentaloma and 55 acromegal...

Introduction: Parathyroid adenomas are rarely large in size. Here, we present a giant cystic parathyroid adenoma presented with pancytopenia.Case report: Twenty two years old female presented with fatigue, bone pain, polyuria, a lump in the neck and pancytopenia. She had a pulsatile mass on the right side of the neck which compressed her trachea. She was evaluated by Hematology since her Hb was 4.7 g/dl, WBC was 2200 u/l platelet count was: 69 000 u/l. B...

Introduction: Osteogenesis imperfecta (OI) is a congenital, generalized connective tissue disorder characterized by severe osteoporosis and bone fragility. OI is most commonly caused by mutations in genes encoding the α-1 and α-2 chains of type I collagen or proteins involved in posttranslational modification of type I collagen. Although, no controlled studies are done, bisphosphonates are used for the treatment of OI. I.v. bisphosphonates are reported to be more eff...

Introduction: Adrenocortical carcinoma (ACC) is a rare cancer (estimated incidence, 0.7 to 2.0 cases per 1 million population per year) with a poor prognosis. Even after seemingly complete surgical resection, most patients develop recurrence within 5 years. The 5-year survival rate is <15% among patients with metastatic disease.Methods: We present the results of six patients with adrenocortical carcinoma followed in our clinic....

Introduction: Acromegaly is a disease caused by excessive secretion of GH. The cause of acromegaly is GH secreting pituitary adenoam in 99% of the cases. It is estimated that 5% of pituitary adenomas become invasive and may grow to gigantic sizes (>4 cm in diameter). Here, we present a 31 years old acromegalic woman with a delayed diagnosis of a giant invasive pituiatary adenoma.Case report: A 31-year-old woman admitted to our hospital for oligomenor...